Specific isoforms of the ubiquitin ligase gene WWP2 are targets of osteoarthritis genetic risk via a differentially methylated DNA sequence

Specific isoforms of the ubiquitin ligase gene WWP2 are targets of osteoarthritis genetic risk via a differentially methylated DNA sequence

Abstract Background Transitioning from a genetic association signal to an effector gene and a targetable molecular mechanism requires the application of functional fine-mapping tools such as reporter assays and genome editing. In this report, we undertook such studies on the osteoarthritis (OA) risk...

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Bibliographic Details
Main Authors: Jack B. Roberts, Olivia L.G. Boldvig, Guillaume Aubourg, S. Tanishq Kanchenapally, David J. Deehan, Sarah J. Rice, John Loughlin
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Arthritis Research & Therapy
Subjects:
Genetics
Epigenetics
DNA methylation
Epigenome editing
WWP2
miR-140
Online Access:https://doi.org/10.1186/s13075-024-03315-8

Internet

https://doi.org/10.1186/s13075-024-03315-8

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