Cardiomyopathy related desmocollin-2 prodomain variants affect the intracellular cadherin transport and processing

Cardiomyopathy related desmocollin-2 prodomain variants affect the intracellular cadherin transport and processing

BackgroundArrhythmogenic cardiomyopathy can be caused by genetic variants in desmosomal cadherins. Since cardiac desmosomal cadherins are crucial for cell-cell-adhesion, their correct localization at the plasma membrane is essential.MethodsNine desmocollin-2 variants at five positions from various p...

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Bibliographic Details
Main Authors: Greta Marie Pohl, Manuel Göz, Anna Gaertner, Andreas Brodehl, Tolga Cimen, Ardan M. Saguner, Eric Schulze-Bahr, Volker Walhorn, Dario Anselmetti, Hendrik Milting
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
desmosome
desmocollin-2
DSC2
prodomain
signal peptide
genetic variants
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1127261/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2023.1127261/full

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