Cas14a1-Mediated Nucleic Acid Diagnostics for Spinal Muscular Atrophy

Cas14a1-Mediated Nucleic Acid Diagnostics for Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is the main genetic cause of infant death. In >95% of the patients with SMA, the disease is caused by a single hotspot pathogenic mutation: homozygous deletion of exon 7 of the survival motor neuron 1 gene (<i>SMN1</i>). Recently, clustered regularly inte...

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Bibliographic Details
Main Authors: Zhiqing Hu, Miaomiao Chen, Chunhua Zhang, Zhuo Li, Mai Feng, Lingqian Wu, Miaojin Zhou, Desheng Liang
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Biosensors
Subjects:
CRISPR/Cas14a1
nucleic acid detection
asymmetric PCR
spinal muscular atrophy
Online Access:https://www.mdpi.com/2079-6374/12/5/268

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https://www.mdpi.com/2079-6374/12/5/268

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