HIV-1 Tat Binding to PCAF Bromodomain: Structural Determinants from Computational Methods

The binding between the HIV-1 trans-activator of transcription (Tat) and p300/(CREB-binding protein)-associated factor (PCAF) bromodomain is a crucial step in the HIV-1 life cycle. However, the structure of the full length acetylated Tat bound to PCAF has not been yet determined experimentally. Acet...

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Bibliographic Details
Main Authors: Paolo Carloni, Mauro Giacca, Giulia Rossetti, Sergio Pantano, Vo Cam Quy
Format: Article
Language:English
Published: MDPI AG 2012-08-01
Series:Biology
Subjects:
Online Access:http://www.mdpi.com/2079-7737/1/2/277