Zerumbone Protects against Carbon Tetrachloride (CCl<sub>4</sub>)-Induced Acute Liver Injury in Mice via Inhibiting Oxidative Stress and the Inflammatory Response: Involving the TLR4/NF-κB/COX-2 Pathway

Zerumbone Protects against Carbon Tetrachloride (CCl<sub>4</sub>)-Induced Acute Liver Injury in Mice via Inhibiting Oxidative Stress and the Inflammatory Response: Involving the TLR4/NF-κB/COX-2 Pathway

The natural compound Zerumbone (hereinafter referred to as ZER), a monocyclic sesquiterpenoid, has been reported to possess many pharmacological properties, including antioxidant and anti-inflammatory properties. This study aimed to investigate the underlying mechanism of ZER against acute liver inj...

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Bibliographic Details
Main Authors: Meilin Wang, Jingling Niu, Lina Ou, Bo Deng, Yingyi Wang, Sanqiang Li
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
Zerumbone
acute liver injury
antioxidant
anti-inflammation
pro-inflammatory cytokine
TNF-α
IL-6
TLR4
NF-κB
COX-2
Online Access:https://www.mdpi.com/1420-3049/24/10/1964

Internet

https://www.mdpi.com/1420-3049/24/10/1964

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