Single-cell and spatial transcriptomics reveals that PTPRG activates the m6A methyltransferase VIRMA to block mitophagy-mediated neuronal death in Alzheimer’s disease

Single-cell and spatial transcriptomics reveals that PTPRG activates the m6A methyltransferase VIRMA to block mitophagy-mediated neuronal death in Alzheimer’s disease

Neuronal death is one of the key pathologies in Alzheimer's disease (AD). How neuronal death begins in AD is far from clear, so clarifying this process may help develop effective therapies. This study collected single-cell RNA sequencing data of 85 AD samples and 83 control samples, covering th...

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Bibliographic Details
Main Authors: Donghua Zou, Xiaohua Huang, Yating Lan, Mika Pan, Jieqiong Xie, Qi Huang, Jingyi Zeng, Chun Zou, Zifei Pei, Cuihua Zou, Yingwei Mao, Jiefeng Luo
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Pharmacological Research
Subjects:
Neuronal death
Single-cell RNA sequencing
Spatial transcriptomics
Mitophagy
N6-methyladenosine
Alzheimer’s disease
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824000422

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http://www.sciencedirect.com/science/article/pii/S1043661824000422

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