TNF-α acts as an immunoregulator in the mouse brain by reducing the incidence of severe disease following Japanese encephalitis virus infection.

TNF-α acts as an immunoregulator in the mouse brain by reducing the incidence of severe disease following Japanese encephalitis virus infection.

Japanese encephalitis virus (JEV) causes acute central nervous system (CNS) disease in humans, in whom the clinical symptoms vary from febrile illness to meningitis and encephalitis. However, the mechanism of severe encephalitis has not been fully elucidated. In this study, using a mouse model, we i...

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Bibliographic Details
Main Authors: Daisuke Hayasaka, Kenji Shirai, Kotaro Aoki, Noriyo Nagata, Dash Sima Simantini, Kazutaka Kitaura, Yuki Takamatsu, Ernest Gould, Ryuji Suzuki, Kouichi Morita
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3733918?pdf=render

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http://europepmc.org/articles/PMC3733918?pdf=render

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