Knockdown of Leptin Receptor Affects Macrophage Phenotype in the Tumor Microenvironment Inhibiting Breast Cancer Growth and Progression

Knockdown of Leptin Receptor Affects Macrophage Phenotype in the Tumor Microenvironment Inhibiting Breast Cancer Growth and Progression

Aberrant leptin (Ob) signaling, a hallmark of obesity, has been recognized to influence breast cancer (BC) biology within the tumor microenvironment (TME). Here, we evaluated the impact of leptin receptor (ObR) knockdown in affecting BC phenotype and in mediating the interaction between tumor cells...

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Bibliographic Details
Main Authors: Luca Gelsomino, Giuseppina Daniela Naimo, Rocco Malivindi, Giuseppina Augimeri, Salvatore Panza, Cinzia Giordano, Ines Barone, Daniela Bonofiglio, Loredana Mauro, Stefania Catalano, Sebastiano Andò
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
breast cancer
leptin
leptin receptor
tumor microenvironment
tumor associated macrophages
immune checkpoint blockade
Online Access:https://www.mdpi.com/2072-6694/12/8/2078

Internet

https://www.mdpi.com/2072-6694/12/8/2078

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