Genome-Wide Analyses for Osteosarcoma in Leonberger Dogs Reveal the <i>CDKN2A/B</i> Gene Locus as a Major Risk Locus

Genome-Wide Analyses for Osteosarcoma in Leonberger Dogs Reveal the <i>CDKN2A/B</i> Gene Locus as a Major Risk Locus

Dogs represent a unique spontaneous cancer model. Osteosarcoma (OSA) is the most common primary bone tumor in dogs (OMIA 001441-9615), and strongly resembles human forms of OSA. Several large- to giant-sized dog breeds, including the Leonberger, have a greatly increased risk of developing OSA. We pe...

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Bibliographic Details
Main Authors: Anna Letko, Katie M. Minor, Elaine M. Norton, Voichita D. Marinescu, Michaela Drögemüller, Emma Ivansson, Kate Megquier, Hyun Ji Noh, Mike Starkey, Steven G. Friedenberg, Kerstin Lindblad-Toh, James R. Mickelson, Cord Drögemüller
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Genes
Subjects:
osteosarcoma
bone cancer
<i>canis familiaris</i>
Leonberger
animal model
<i>CDKN2A/B</i>
Online Access:https://www.mdpi.com/2073-4425/12/12/1964

Internet

https://www.mdpi.com/2073-4425/12/12/1964

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