Dual orexin receptor antagonist drug suvorexant can help in amelioration of predictable chronic mild stress-induced hyperalgesia

Dual orexin receptor antagonist drug suvorexant can help in amelioration of predictable chronic mild stress-induced hyperalgesia

Aims: This study aimed to evaluate the involvement of the orexin system in predictable chronic mild stress (PCMS) and the effects of suvorexant, a dual orexin receptor antagonist, on nociceptive behavior in PCMS. Materials and methods: Male C57BL/6 J mice were separated into various PCMS groups: a c...

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Bibliographic Details
Main Authors: Parimal Chavan, Sachiko Chikahisa, Tetsuya Shiuchi, Noriyuki Shimizu, Junhel Dalanon, Kazuo Okura, Hiroyoshi Séi, Yoshizo Matsuka
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Brain Research Bulletin
Subjects:
Predictable chronic mild stress (PCMS)
Orexin
Hyperalgesia
Suvorexant
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923022001745

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http://www.sciencedirect.com/science/article/pii/S0361923022001745

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