Quinoxalines against Leishmania amazonensis: SAR study, proposition of a new derivative, QSAR prediction, synthesis, and biological evaluation

Quinoxalines against Leishmania amazonensis: SAR study, proposition of a new derivative, QSAR prediction, synthesis, and biological evaluation

Abstract Neglected tropical diseases, such as leishmaniasis, lead to serious limitations to the affected societies. In this work, a structure–activity relationship (SAR) study was developed with a series of quinoxaline derivatives, active against the promastigote forms of Leishmania amazonensis. As...

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Bibliographic Details
Main Authors: Anna Carolina Silva de Jesus Passaes, Juliana Arantes Dantas, Fernanda Landim Lopes, Diego Pereira Sangi, Magaly Girão Albuquerque, Celso Vataru Nakamura, Julliane Yoneda
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-45436-1

Internet

https://doi.org/10.1038/s41598-023-45436-1

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