Antigen-Specific IFN-γ/IL-17-Co-Producing CD4<sup>+</sup> T-Cells are the Determinants for Protective Efficacy of Tuberculosis Subunit Vaccine

Antigen-Specific IFN-γ/IL-17-Co-Producing CD4<sup>+</sup> T-Cells are the Determinants for Protective Efficacy of Tuberculosis Subunit Vaccine

The antigen-specific Th17 responses in the lungs for improved immunity against <i>Mycobacterium tuberculosis</i> (Mtb) infection are incompletely understood. Tuberculosis (TB) vaccine candidate HSP90-ESAT-6 (E6), given as a Bacillus Calmette-Guérin (BCG)-prime boost regimen, confers supe...

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Bibliographic Details
Main Authors: Han-Gyu Choi, Kee Woong Kwon, Seunga Choi, Yong Woo Back, Hye-Soo Park, Soon Myung Kang, Eunsol Choi, Sung Jae Shin, Hwa-Jung Kim
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Vaccines
Subjects:
<i>Mycobacterium tuberculosis</i>
BCG-prime boost
IFN-γ/IL-17
multifunctional T cells
phagosome maturation
Online Access:https://www.mdpi.com/2076-393X/8/2/300

Internet

https://www.mdpi.com/2076-393X/8/2/300

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