Link between structural connectivity of the medial forebrain bundle, functional connectivity of the ventral tegmental area, and anhedonia in unipolar depression

Link between structural connectivity of the medial forebrain bundle, functional connectivity of the ventral tegmental area, and anhedonia in unipolar depression

The ventral tegmental area (VTA), nucleus accumbens (NAcc), and prefrontal cortex (PFC) are essential for experiencing pleasure and initiating motivated behaviour. The VTA, NAcc, and PFC are connected through the medial forebrain bundle (MFB). In humans, two branches have been described: an infero-m...

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Bibliographic Details
Main Authors: Tobias Bracht, Nicolas Mertse, Sebastian Walther, Karin Lüdi, Sigrid Breit, Andrea Federspiel, Roland Wiest, Niklaus Denier
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:NeuroImage: Clinical
Subjects:
Anhedonia
Depression
Diffusion tensor imaging
Functional MRI
Medial forebrain bundle
Reward system
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158222000262

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http://www.sciencedirect.com/science/article/pii/S2213158222000262

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