N,N-Dimethylaminoxy Carbonyl, a Polar Protecting Group for Efficient Peptide Synthesis

N,N-Dimethylaminoxy Carbonyl, a Polar Protecting Group for Efficient Peptide Synthesis

Peptide coupling with minimal protection is one of the desired methods for the synthesis of peptides and proteins. To achieve regioselective amide bond formation, side chain protection is often essential; however, protecting groups potentially diminish peptide solubility and render the polar polyami...

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Bibliographic Details
Main Authors: Ryo Okamoto, Emiko Ono, Masayuki Izumi, Yasuhiro Kajihara
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Chemistry
Subjects:
N,N-dimethylaminoxy carbonyl
Dmaoc
Dbz
peptide coupling
solid phase peptide synthesis
chemical ligation
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00173/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00173/full

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