Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming

Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming

Abstract Serine hydroxymethyltransferase 2 (SHMT2) plays an important role in converting serine to glycine and supplying carbon to one-carbon metabolism to sustain cancer cell proliferation. However, the expression, function, and underlying mechanisms of SHMT2 in clear cell renal cell carcinoma (ccR...

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Bibliographic Details
Main Authors: Zhangnan Liu, Mengzhen Fan, Junqing Hou, Sijing Pan, Yanxin Xu, Hailong Zhang, Chen Liu, Xiangjun Hao, Xia Li, Huijuan Wang
Format: Article
Language:English
Published: Nature Publishing Group 2023-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05677-4

Internet

https://doi.org/10.1038/s41419-023-05677-4

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