Functional assessment of missense variants of uncertain significance in the cancer susceptibility gene PALB2

Functional assessment of missense variants of uncertain significance in the cancer susceptibility gene PALB2

Abstract Germline PALB2 pathogenic variants are associated with an increased lifetime risk for breast, pancreatic, and ovarian cancer. However, the interpretation of the pathogenicity of numerous PALB2 missense variants of uncertain significance (VUSs) identified in germline genetic testing remains...

Full description

Bibliographic Details
Main Authors: Shijie Wu, Lina Qi, Huihui Chen, Kun Zhang, Jiapan He, Xianan Guo, Lu Shen, Yunxiang Zhou, Xi Zhong, Shu Zheng, Jiaojiao Zhou, Yiding Chen
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-022-00454-6

Internet

https://doi.org/10.1038/s41523-022-00454-6

Similar Items