Prostaglandin E2 as transduction enhancer affects competitive engraftment of human hematopoietic stem and progenitor cells

Prostaglandin E2 as transduction enhancer affects competitive engraftment of human hematopoietic stem and progenitor cells

Ex vivo gene therapy (GT) is a promising treatment for inherited genetic diseases. An ideal transduction protocol should determine high gene marking in long-term self-renewing hematopoietic stem cells (HSCs), preserving their repopulation potential during in vitro manipulation. In the context of the...

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Bibliographic Details
Main Authors: Valentina Poletti, Annita Montepeloso, Danilo Pellin, Alessandra Biffi
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
gene therapy
transduction enhancer
lentiviral vector
prostaglandin E2
HSPCs
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123001705

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http://www.sciencedirect.com/science/article/pii/S2329050123001705

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