Ranitidine Alleviates Anxiety-like Behaviors and Improves the Density of Pyramidal Neurons upon Deactivation of Microglia in the CA3 Region of the Hippocampus in a Cysteamine HCl-Induced Mouse Model of Gastrointestinal Disorder

Ranitidine Alleviates Anxiety-like Behaviors and Improves the Density of Pyramidal Neurons upon Deactivation of Microglia in the CA3 Region of the Hippocampus in a Cysteamine HCl-Induced Mouse Model of Gastrointestinal Disorder

Elevated levels of histamine cause over-secretion of gastric hydrochloric acid (HCl), leading to gastrointestinal (GI) disorders and anxiety. Ranitidine is an antihistamine drug widely used in the management of GI disorders, as it works by blocking the histamine−2 receptors in parietal cells, thereb...

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Bibliographic Details
Main Authors: Divya Bharathi Selvaraj, Jemi Feiona Vergil Andrews, Muthuswamy Anusuyadevi, Mahesh Kandasamy
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Brain Sciences
Subjects:
anxiety
cysteamine HCl
histamine
ranitidine
elevated plus maze
microglia
Online Access:https://www.mdpi.com/2076-3425/13/2/266

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https://www.mdpi.com/2076-3425/13/2/266

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