Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer

Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer

Abstract Background Mitochondrial dynamics underlies malignant transformation, cancer progression, and response to treatment. Current research presents conflicting evidence for functions of mitochondrial fission and fusion in tumor progression. Here, we investigated how mitochondrial fission and fus...

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Bibliographic Details
Main Authors: Brock A. Humphries, Alyssa C. Cutter, Johanna M. Buschhaus, Yu-Chih Chen, Tonela Qyli, Dilrukshika S. W. Palagama, Samantha Eckley, Tanner H. Robison, Avinash Bevoor, Benjamin Chiang, Henry R. Haley, Saswat Sahoo, Phillip C. Spinosa, Dylan B. Neale, Jagadish Boppisetti, Debashis Sahoo, Pradipta Ghosh, Joerg Lahann, Brian D. Ross, Eusik Yoon, Kathryn E. Luker, Gary D. Luker
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Breast Cancer Research
Subjects:
Triple-negative breast cancer
ERK
Akt
Fluorescence microscopy
Mitochondrial fission
Mitochondrial fusion
Online Access:http://link.springer.com/article/10.1186/s13058-020-01301-x

Internet

http://link.springer.com/article/10.1186/s13058-020-01301-x

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