In vitro sepsis induces Nociceptin/Orphanin FQ receptor (NOP) expression in primary human vascular endothelial but not smooth muscle cells

In vitro sepsis induces Nociceptin/Orphanin FQ receptor (NOP) expression in primary human vascular endothelial but not smooth muscle cells

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Sepsis is a dysregulated host response to infection that can cause widespread effects on other organs including cardiovascular depression, hypotension and organ failure. The receptor for Nociceptin/Orphanin FQ (N/OFQ), NOP is expressed on immune cells and these cells can release the peptide. Exogeno...

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Bibliographic Details
Main Authors: Mark F. Bird, Barbara Gallacher-Horley, John McDonald, David G. McVey, Fatin Al-Janabi, Remo Guerrini, Girolamo Calo, Shu Ye, Jonathan P. Thompson, David G. Lambert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477356/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477356/?tool=EBI

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