Transcriptome-Wide Analysis of RNA N6-Methyladenosine Modification in Adriamycin-Resistant Acute Myeloid Leukemia Cells

Transcriptome-Wide Analysis of RNA N6-Methyladenosine Modification in Adriamycin-Resistant Acute Myeloid Leukemia Cells

Acute myeloid leukemia (AML) is one of the most aggressive hematopoietic malignancies. Patients still suffer from refractory/relapsed disease after anthracycline-based therapy, which leads to a poor prognosis. N6-Methyladenosine (m6A) is the most abundant post-transcriptional modification in eukaryo...

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Bibliographic Details
Main Authors: Shu Fang, Bo Peng, Yanan Wen, Jingjing Yang, Hao Wang, Ziwei Wang, Kun Qian, Yan Wei, Yifan Jiao, Chunji Gao, Liping Dou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Genetics
Subjects:
acute myeloid leukemia
drug resistance
N6-methyladenosine
gene expression
METTL3
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.833694/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.833694/full

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