A haplotype-resolved genome assembly of the Nile rat facilitates exploration of the genetic basis of diabetes

A haplotype-resolved genome assembly of the Nile rat facilitates exploration of the genetic basis of diabetes

Abstract Background The Nile rat (Avicanthis niloticus) is an important animal model because of its robust diurnal rhythm, a cone-rich retina, and a propensity to develop diet-induced diabetes without chemical or genetic modifications. A closer similarity to humans in these aspects, compared to the...

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Main Authors: Huishi Toh, Chentao Yang, Giulio Formenti, Kalpana Raja, Lily Yan, Alan Tracey, William Chow, Kerstin Howe, Lucie A. Bergeron, Guojie Zhang, Bettina Haase, Jacquelyn Mountcastle, Olivier Fedrigo, John Fogg, Bogdan Kirilenko, Chetan Munegowda, Michael Hiller, Aashish Jain, Daisuke Kihara, Arang Rhie, Adam M. Phillippy, Scott A. Swanson, Peng Jiang, Dennis O. Clegg, Erich D. Jarvis, James A. Thomson, Ron Stewart, Mark J. P. Chaisson, Yury V. Bukhman
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Biology
Subjects:
Arvicanthis niloticus
Genome
Diurnal
Diabetes
Long-read genome assembly
Heterozygosity
Online Access:https://doi.org/10.1186/s12915-022-01427-8

Internet

https://doi.org/10.1186/s12915-022-01427-8

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