A virtual scalable model of the Hepatic Lobule for acetaminophen hepatotoxicity prediction

A virtual scalable model of the Hepatic Lobule for acetaminophen hepatotoxicity prediction

Abstract Addressing drug-induced liver injury is crucial in drug development, often causing Phase III trial failures and market withdrawals. Traditional animal models fail to predict human liver toxicity accurately. Virtual twins of human organs present a promising solution. We introduce the Virtual...

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Bibliographic Details
Main Authors: Stelian Camara Dit Pinto, Jalal Cherkaoui, Debarshi Ghosh, Valentine Cazaubon, Kenza E. Benzeroual, Steven M. Levine, Mohammed Cherkaoui, Gagan K. Sood, Sharmila Anandasabapathy, Sadhna Dhingra, John M. Vierling, Nicolas R. Gallo
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:npj Digital Medicine
Online Access:https://doi.org/10.1038/s41746-024-01349-5

Internet

https://doi.org/10.1038/s41746-024-01349-5

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