Local application of engineered insulin-like growth factor I mRNA demonstrates regenerative therapeutic potential in vivo

Local application of engineered insulin-like growth factor I mRNA demonstrates regenerative therapeutic potential in vivo

Insulin-like growth factor I (IGF-I) is a growth-promoting anabolic hormone that fosters cell growth and tissue homeostasis. IGF-I deficiency is associated with several diseases, including growth disorders and neurological and musculoskeletal diseases due to impaired regeneration. Despite the vast r...

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Bibliographic Details
Main Authors: Justin S. Antony, Pascale Birrer, Claudia Bohnert, Sina Zimmerli, Petra Hillmann, Hervé Schaffhauser, Christine Hoeflich, Andreas Hoeflich, Ramzi Khairallah, Andreas T. Satoh, Isabelle Kappeler, Isabel Ferreira, Klaas P. Zuideveld, Friedrich Metzger
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: RNA/DNA Editing
IGF-I
mRNA therapy
muscle injury
disc herniation
regeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123002731

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http://www.sciencedirect.com/science/article/pii/S2162253123002731

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