MET Suppresses Epithelial VEGFR2 via Intracrine VEGF-induced Endoplasmic Reticulum-associated Degradation

MET Suppresses Epithelial VEGFR2 via Intracrine VEGF-induced Endoplasmic Reticulum-associated Degradation

Hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) drive cancer through their respective receptors, MET and VEGF receptor 2 (VEGFR2). VEGFR2 inhibits MET by promoting MET dephosphorylation. However, whether MET conversely regulates VEGFR2 remains unknown. Here we show that...

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Bibliographic Details
Main Authors: Tom T. Chen, Ellen Filvaroff, Jing Peng, Scot Marsters, Adrian Jubb, Hartmut Koeppen, Mark Merchant, Avi Ashkenazi
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:EBioMedicine
Subjects:
HGF
VEGF
ERAD
PI3 kinase
AKT
MEK
IRE1
XBP1
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415000882

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http://www.sciencedirect.com/science/article/pii/S2352396415000882

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