Crumpled Polymer with Loops Recapitulates Key Features of Chromosome Organization
Chromosomes are exceedingly long topologically constrained polymers compacted in a cell nucleus. We recently suggested that chromosomes are organized into loops by an active process of loop extrusion. Yet loops remain elusive to direct observations in living cells; detection and characterization of...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Physical Society
2023-11-01
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| Series: | Physical Review X |
| Online Access: | http://doi.org/10.1103/PhysRevX.13.041029 |