To Develop With Or Without The Prion Protein
The deletion of the cellular form of the prion protein (PrPC) in mouse, goat and cattle has no drastic phenotypic consequence. This stands in apparent contradiction with PrPC quasi- ubiquitous expression and conserved primary and tertiary structures in mammals, and its pivotal role in neurodegenerat...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-10-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcell.2014.00058/full |
| _version_ | 1811243391071027200 |
|---|---|
| author | Sophie eHalliez Bruno ePasset Séverine eMartin-Lannerée Séverine eMartin-Lannerée Julia eHernandez-Rapp Julia eHernandez-Rapp Hubert eLaude Sophie eMouillet-Richard Sophie eMouillet-Richard Jean-Luc eVilotte Vincent eBéringue |
| author_facet | Sophie eHalliez Bruno ePasset Séverine eMartin-Lannerée Séverine eMartin-Lannerée Julia eHernandez-Rapp Julia eHernandez-Rapp Hubert eLaude Sophie eMouillet-Richard Sophie eMouillet-Richard Jean-Luc eVilotte Vincent eBéringue |
| author_sort | Sophie eHalliez |
| collection | DOAJ |
| description | The deletion of the cellular form of the prion protein (PrPC) in mouse, goat and cattle has no drastic phenotypic consequence. This stands in apparent contradiction with PrPC quasi- ubiquitous expression and conserved primary and tertiary structures in mammals, and its pivotal role in neurodegenerative diseases such as prion and Alzheimer’s diseases. In zebrafish embryos, depletion of PrP ortholog leads to a severe loss-of-function phenotype. This raises the question of a potential role of PrPC in the development of all vertebrates. This view is further supported by the early expression of the PrPC encoding gene (Prnp) in many tissues of the mouse embryo, the transient disruption of a broad number of cellular pathways in early Prnp-/- mouse embryos, and a growing body of evidence for PrPC involvement in the regulation of cell proliferation and differentiation in various types of mammalian stem cells and progenitors. Finally, several studies in both zebrafish embryos and in mammalian cells and tissues in formation support a role for PrPC in cell adhesion, extra-cellular matrix interactions and cytoskeleton. In this review, we summarize and compare the different models used to decipher PrPC functions at early developmental stages during embryo- and organo- genesis and discuss their relevance. |
| first_indexed | 2024-04-12T14:06:35Z |
| format | Article |
| id | doaj.art-9c7c726243d14f8f93c65d97106d4efe |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-12T14:06:35Z |
| publishDate | 2014-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-9c7c726243d14f8f93c65d97106d4efe2022-12-22T03:30:03ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2014-10-01210.3389/fcell.2014.00058111417To Develop With Or Without The Prion ProteinSophie eHalliez0Bruno ePasset1Séverine eMartin-Lannerée2Séverine eMartin-Lannerée3Julia eHernandez-Rapp4Julia eHernandez-Rapp5Hubert eLaude6Sophie eMouillet-Richard7Sophie eMouillet-Richard8Jean-Luc eVilotte9Vincent eBéringue10INRAINRAINSERMUniversité Paris Descartes, Sorbonne Paris CitéINSERMUniversité Paris Descartes, Sorbonne Paris CitéINRAINSERMUniversité Paris Descartes, Sorbonne Paris CitéINRAINRAThe deletion of the cellular form of the prion protein (PrPC) in mouse, goat and cattle has no drastic phenotypic consequence. This stands in apparent contradiction with PrPC quasi- ubiquitous expression and conserved primary and tertiary structures in mammals, and its pivotal role in neurodegenerative diseases such as prion and Alzheimer’s diseases. In zebrafish embryos, depletion of PrP ortholog leads to a severe loss-of-function phenotype. This raises the question of a potential role of PrPC in the development of all vertebrates. This view is further supported by the early expression of the PrPC encoding gene (Prnp) in many tissues of the mouse embryo, the transient disruption of a broad number of cellular pathways in early Prnp-/- mouse embryos, and a growing body of evidence for PrPC involvement in the regulation of cell proliferation and differentiation in various types of mammalian stem cells and progenitors. Finally, several studies in both zebrafish embryos and in mammalian cells and tissues in formation support a role for PrPC in cell adhesion, extra-cellular matrix interactions and cytoskeleton. In this review, we summarize and compare the different models used to decipher PrPC functions at early developmental stages during embryo- and organo- genesis and discuss their relevance.http://journal.frontiersin.org/Journal/10.3389/fcell.2014.00058/fullCell AdhesionCytoskeletonStem Cellsdevelopmentprion proteinneural development |
| spellingShingle | Sophie eHalliez Bruno ePasset Séverine eMartin-Lannerée Séverine eMartin-Lannerée Julia eHernandez-Rapp Julia eHernandez-Rapp Hubert eLaude Sophie eMouillet-Richard Sophie eMouillet-Richard Jean-Luc eVilotte Vincent eBéringue To Develop With Or Without The Prion Protein Frontiers in Cell and Developmental Biology Cell Adhesion Cytoskeleton Stem Cells development prion protein neural development |
| title | To Develop With Or Without The Prion Protein |
| title_full | To Develop With Or Without The Prion Protein |
| title_fullStr | To Develop With Or Without The Prion Protein |
| title_full_unstemmed | To Develop With Or Without The Prion Protein |
| title_short | To Develop With Or Without The Prion Protein |
| title_sort | to develop with or without the prion protein |
| topic | Cell Adhesion Cytoskeleton Stem Cells development prion protein neural development |
| url | http://journal.frontiersin.org/Journal/10.3389/fcell.2014.00058/full |
| work_keys_str_mv | AT sophieehalliez todevelopwithorwithouttheprionprotein AT brunoepasset todevelopwithorwithouttheprionprotein AT severineemartinlanneree todevelopwithorwithouttheprionprotein AT severineemartinlanneree todevelopwithorwithouttheprionprotein AT juliaehernandezrapp todevelopwithorwithouttheprionprotein AT juliaehernandezrapp todevelopwithorwithouttheprionprotein AT hubertelaude todevelopwithorwithouttheprionprotein AT sophieemouilletrichard todevelopwithorwithouttheprionprotein AT sophieemouilletrichard todevelopwithorwithouttheprionprotein AT jeanlucevilotte todevelopwithorwithouttheprionprotein AT vincenteberingue todevelopwithorwithouttheprionprotein |