Fibrosis independent atrial fibrillation in older patients is driven by substrate leukocyte infiltration: diagnostic and prognostic implications to patients undergoing cardiac surgery

Fibrosis independent atrial fibrillation in older patients is driven by substrate leukocyte infiltration: diagnostic and prognostic implications to patients undergoing cardiac surgery

Abstract Background The objectives of the study were to characterize and quantify cellular inflammation and structural remodeling of human atria and correlate findings with molecular markers of inflammation and patient surrogate outcome. Methods Voluntary participants undergoing heart surgery were e...

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Bibliographic Details
Main Authors: Christie M. Aguiar, Kareem Gawdat, Stephanie Legere, Jean Marshall, Ansar Hassan, Petra C. Kienesberger, Thomas Pulinilkunnil, Mathieu Castonguay, Keith R. Brunt, Jean-Francois Legare
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Translational Medicine
Subjects:
Atrial fibrillation
Cytokines
Macrophages (MoΦ)
Human atrium
Cardiac surgery
Leucocyte infiltration
Online Access:https://doi.org/10.1186/s12967-019-02162-5

Internet

https://doi.org/10.1186/s12967-019-02162-5

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