Environmental BPDE induced human trophoblast cell apoptosis by up-regulating lnc-HZ01/p53 positive feedback loop

Environmental BPDE induced human trophoblast cell apoptosis by up-regulating lnc-HZ01/p53 positive feedback loop

Human trophoblast cell apoptosis may induce miscarriage. Trophoblast cells are sensitive to environmental BaP-7,8-dihydrodiol-9,10-epoxide (BPDE). However, how BPDE induces human trophoblast cell apoptosis is still largely elusive. In this work, we used BPDE-treated human trophoblast cells and villo...

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Bibliographic Details
Main Authors: Xinying Huang, Chenglong Ma, Wenxin Huang, Mengyuan Dai, Jingjing Yang, Xiaole Xu, Yuanlv Deng, Yang Yang, Huidong Zhang
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Environmental BaP or BPDE
Non-coding lncRNA-HZ01
Female trophoblast cell apoptosis
MDM2/p53/caspase-3
Miscarriage
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651322004043

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http://www.sciencedirect.com/science/article/pii/S0147651322004043

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