XPO1 regulates erythroid differentiation and is a new target for the treatment of β-thalassemia

XPO1 regulates erythroid differentiation and is a new target for the treatment of β-thalassemia

β-thalassemia major (β-TM) is an inherited hemoglobinopathy caused by a quantitative defect in the synthesis of β-globin chains of hemoglobin, leading to the accumulation of free a-globin chains that aggregate and cause ineffective erythropoiesis. We have previously demonstrated that terminal eryth...

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Bibliographic Details
Main Authors: Flavia Guillem, Michaël Dussiot, Elia Colin, Thunwarat Suriyun, Jean Benoit Arlet, Nicolas Goudin, Guillaume Marcion, Renaud Seigneuric, Sebastien Causse, Patrick Gonin, Marc Gastou, Marc Deloger, Julien Rossignol, Mathilde Lamarque, Zakia Belaid Choucair, Emilie Fleur Gautier, Sarah Ducamp, Julie Vandekerckhove, Ivan C. Moura, Thiago Trovati Maciel, Carmen Garrido, Xiuli An, Patrick Mayeux, Narla Mohandas, Geneviève Courtois, Olivier Hermine
Format: Article
Language:English
Published: Ferrata Storti Foundation 2019-11-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/9853

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https://haematologica.org/article/view/9853

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