Sivelestat sodium attenuates acute lung injury by inhibiting JNK/NF-κB and activating Nrf2/HO-1 signaling pathways

Sivelestat sodium attenuates acute lung injury by inhibiting JNK/NF-κB and activating Nrf2/HO-1 signaling pathways

Sivelestat sodium (SIV), a neutrophil elastase inhibitor, is mainly used for the clinical treatment of acute respiratory distress syndrome (ARDS) or acute lung injury (ALI). However, studies investigating the effects of SIV treatment of ALI are limited. Therefore, this study investigated the potenti...

Full description

Bibliographic Details
Main Authors: Hong Zhang, Jun Zeng, Jiankang Li, Huankai Gong, Meiling Chen, Quan Li, Shengxing Liu, Shanjun Luo, Huanxiang Dong, Yingke Xu, Huanling Duan, Ling Haung, Chuanzhu Lv
Format: Article
Language:English
Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2023-05-01
Series:Biomolecules & Biomedicine
Subjects:
Sivelestat sodium
acute lung injury
inflammation
oxidative stress
JNK/NF-κB
Nrf2/HO-1
Online Access:https://www.bjbms.org/ojs/index.php/bjbms/article/view/8549

Internet

https://www.bjbms.org/ojs/index.php/bjbms/article/view/8549

Similar Items