Single-Cell RNA-seq Analysis Reveals Cellular Functional Heterogeneity in Dermis Between Fibrotic and Regenerative Wound Healing Fates

Single-Cell RNA-seq Analysis Reveals Cellular Functional Heterogeneity in Dermis Between Fibrotic and Regenerative Wound Healing Fates

BackgroundFibrotic scars are common in both human and mouse skin wounds. However, wound-induced hair neogenesis in the murine wounding models often results in regenerative repair response. Herein, we aimed to uncover cellular functional heterogeneity in dermis between fibrotic and regenerative wound...

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Bibliographic Details
Main Authors: Cao-Jie Chen, Hiroki Kajita, Kento Takaya, Noriko Aramaki-Hattori, Shigeki Sakai, Toru Asou, Kazuo Kishi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
skin wound healing
fibrosis
regeneration
myofibroblast
macrophage
single-cell RNA sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.875407/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.875407/full

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