A Natural Compound Containing a Disaccharide Structure of Glucose and Rhamnose Identified as Potential N-Glycanase 1 (NGLY1) Inhibitors

A Natural Compound Containing a Disaccharide Structure of Glucose and Rhamnose Identified as Potential N-Glycanase 1 (NGLY1) Inhibitors

N-glycanase 1 (NGLY1) is an essential enzyme involved in the deglycosylation of misfolded glycoproteins through the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which could hydrolyze N-glycan from N-glycoprotein or N-glycopeptide in the cytosol. Recent studies indicated that NGL...

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Bibliographic Details
Main Authors: Ruijie Liu, Jingjing Gu, Yilin Ye, Yuxin Zhang, Shaoxing Zhang, Qiange Lin, Shuying Yuan, Yanwen Chen, Xinrong Lu, Yongliang Tong, Shaoxian Lv, Li Chen, Guiqin Sun
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Molecules
Subjects:
N-glycanase 1 (NGLY1)
NGLY1 inhibitor
natural compound
structure-based virtual screening
Online Access:https://www.mdpi.com/1420-3049/28/23/7758

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https://www.mdpi.com/1420-3049/28/23/7758

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