CTCF maintains regulatory homeostasis of cancer pathways

CTCF maintains regulatory homeostasis of cancer pathways

Abstract Background CTCF binding to DNA helps partition the mammalian genome into discrete structural and regulatory domains. Complete removal of CTCF from mammalian cells causes catastrophic genome dysregulation, likely due to widespread collapse of 3D chromatin looping and alterations to inter- an...

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Bibliographic Details
Main Authors: Sarah J. Aitken, Ximena Ibarra-Soria, Elissavet Kentepozidou, Paul Flicek, Christine Feig, John C. Marioni, Duncan T. Odom
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Genome Biology
Subjects:
CTCF
Transcription
Hemizygosity
Cancer
Chromatin state
Chromatin architecture
Online Access:http://link.springer.com/article/10.1186/s13059-018-1484-3

Internet

http://link.springer.com/article/10.1186/s13059-018-1484-3

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