Effect of Diacetylcurcumin Manganese Complex on Rotenone-Induced Oxidative Stress, Mitochondria Dysfunction, and Inflammation in the SH-SY5Y Parkinson’s Disease Cell Model

Effect of Diacetylcurcumin Manganese Complex on Rotenone-Induced Oxidative Stress, Mitochondria Dysfunction, and Inflammation in the SH-SY5Y Parkinson’s Disease Cell Model

Diacetylcurcumin manganese complex (DiAc-Cp-Mn) is a diacetylcurcumin (DiAc-Cp) derivative synthesized with Mn (II) to mimic superoxide dismutase (SOD). It exhibited superior reactive oxygen species (ROS) scavenging efficacy, particularly for the superoxide radical. The present study investigated th...

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Bibliographic Details
Main Authors: Ekanong Pirunkaset, Chantana Boonyarat, Juthamart Maneenet, Charinya Khamphukdee, Supawadee Daodee, Orawan Monthakantirat, Suresh Awale, Anake Kijjoa, Yaowared Chulikhit
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Molecules
Subjects:
diacetylcurcumin manganese complex
Parkinson’s disease
oxidative stress
SOD mimics
Nrf2 regulation
Online Access:https://www.mdpi.com/1420-3049/29/5/957

Internet

https://www.mdpi.com/1420-3049/29/5/957

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