Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling

Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling

Pyruvate kinase M2 (PKM2) is a key enzyme of glycolysis, which is highly expressed in many tumor cells, and has emerged as an important player in tumor progression and metastasis. However, the functional roles of PKM2 in tumor metastasis remain elusive. Here we showed that PKM2 promoted prostate can...

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Bibliographic Details
Main Authors: Wenjing Guo, Zhishuai Zhang, Guihuan Li, Xiaoju Lai, Ruonan Gu, Wanfu Xu, Hua Chen, Zhe Xing, Liping Chen, Jiabi Qian, Shiyuan Xu, Fangyin Zeng, Fan Deng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Oncology
Subjects:
pyruvate kinase M2
ERK1/2
cyclooxygenase 2
tumor metastasis
prostate cancer
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.544288/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.544288/full

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