Tissue distribution and abuse potential of prucalopride: findings from non-clinical and clinical studies

Tissue distribution and abuse potential of prucalopride: findings from non-clinical and clinical studies

Background: Prucalopride is a selective serotonin type 4 (5-HT4) receptor agonist indicated for treatment of chronic idiopathic constipation (CIC) in adults (2 mg orally, daily). 5-HT4 receptors are present in the central nervous system; therefore, non-clinical and clinical assessments were performe...

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Bibliographic Details
Main Authors: Katayoun Derakhchan, Zhen Lou, Hong Wang, Robert Baughman
Format: Article
Language:English
Published: BioExcel Publishing Ltd 2023-02-01
Series:Drugs in Context
Subjects:
central nervous system
constipation
drug abuse
drug toxicity
pharmacokinetics
pharmacology
prucalopride
toxicology
Online Access:https://www.drugsincontext.com/tissue-distribution-and-abuse-potential-of-prucalopride-findings-from-non-clinical-and-clinical-studies/

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https://www.drugsincontext.com/tissue-distribution-and-abuse-potential-of-prucalopride-findings-from-non-clinical-and-clinical-studies/

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