ACAT1 deficiency in myeloid cells promotes glioblastoma progression by enhancing the accumulation of myeloid-derived suppressor cells

ACAT1 deficiency in myeloid cells promotes glioblastoma progression by enhancing the accumulation of myeloid-derived suppressor cells

Glioblastoma (GBM) is a highly aggressive and lethal brain tumor with an immunosuppressive tumor microenvironment (TME). In this environment, myeloid cells, such as myeloid-derived suppressor cells (MDSCs), play a pivotal role in suppressing antitumor immunity. Lipometabolism is closely related to t...

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Bibliographic Details
Main Authors: Mingjin Wang, Weida Wang, Shen You, Zhenyan Hou, Ming Ji, Nina Xue, Tingting Du, Xiaoguang Chen, Jing Jin
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Glioblastoma
Myeloid cells
Myeloid-derived suppressor cells
Acetyl-CoA acetyltransferase 1
CXCL1
Tumor microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523003581

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http://www.sciencedirect.com/science/article/pii/S2211383523003581

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