Glioblastoma-Derived Three-Dimensional Ex Vivo Models to Evaluate Effects and Efficacy of Tumor Treating Fields (TTFields)

Glioblastoma-Derived Three-Dimensional Ex Vivo Models to Evaluate Effects and Efficacy of Tumor Treating Fields (TTFields)

Glioblastoma (GBM) displays a wide range of inter- and intra-tumoral heterogeneity contributing to therapeutic resistance and relapse. Although Tumor Treating Fields (TTFields) are effective for the treatment of GBM, there is a lack of ex vivo models to evaluate effects on patients’ tumor biology or...

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Bibliographic Details
Main Authors: Vera Nickl, Ellina Schulz, Ellaine Salvador, Laureen Trautmann, Leopold Diener, Almuth F. Kessler, Camelia M. Monoranu, Faramarz Dehghani, Ralf-Ingo Ernestus, Mario Löhr, Carsten Hagemann
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
glioblastoma
Tumor Treating Fields (TTFields)
organotypic hippocampal slice cultures (OHSC)
organoids
tumor slice cultures
3D ex vivo models
Online Access:https://www.mdpi.com/2072-6694/14/21/5177

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https://www.mdpi.com/2072-6694/14/21/5177

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