Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progression.

Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progression.

The systematic identification of genetic events driving cellular transformation and tumor progression in the absence of a highly recurrent oncogenic driver mutation is a challenge in cutaneous oncology. In cutaneous squamous cell carcinoma (cuSCC), the high UV-induced mutational burden poses a hurdl...

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Bibliographic Details
Main Authors: Aziz Aiderus, Justin Y Newberg, Liliana Guzman-Rojas, Ana M Contreras-Sandoval, Amanda L Meshey, Devin J Jones, Felipe Amaya-Manzanares, Roberto Rangel, Jerrold M Ward, Song-Choon Lee, Kenneth Hon-Kim Ban, Keith Rogers, Susan M Rogers, Luxmanan Selvanesan, Leslie A McNoe, Neal G Copeland, Nancy A Jenkins, Kenneth Y Tsai, Michael A Black, Karen M Mann, Michael B Mann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-08-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009094

Internet

https://doi.org/10.1371/journal.pgen.1009094

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