Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation

Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation

In bacteria, the regulation of gene expression by cis-acting transcriptional riboswitches located in the 5'-untranslated regions of messenger RNA requires the temporal synchronization of RNA synthesis and ligand binding-dependent conformational refolding. Ligand binding to the aptamer domain of...

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Bibliographic Details
Main Authors: Hannah Steinert, Florian Sochor, Anna Wacker, Janina Buck, Christina Helmling, Fabian Hiller, Sara Keyhani, Jonas Noeske, Steffen Grimm, Martin M Rudolph, Heiko Keller, Rachel Anne Mooney, Robert Landick, Beatrix Suess, Boris Fürtig, Jens Wöhnert, Harald Schwalbe
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-05-01
Series:eLife
Subjects:
RNA
riboswitches
meta-stable structures
folding
transcription
kinetics
Online Access:https://elifesciences.org/articles/21297

Internet

https://elifesciences.org/articles/21297

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