Compounds used to produce cloned animals are genotoxic and mutagenic in mammalian assays in vitro and in vivo

The compounds 6-dimethylaminopurine and cycloheximide promote the successful production of cloned mammals and have been used in the development of embryos produced by somatic cell nuclear transfer. This study investigated the effects of 6-dimethylaminopurine and cycloheximide in vitro, using the thi...

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Bibliographic Details
Main Authors: R.J. Oliveira, M.S. Mantovani, A.F. da Silva, J.R. Pesarini, M.O. Mauro, L.R. Ribeiro
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2014-04-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000400287&lng=en&tlng=en