Compounds used to produce cloned animals are genotoxic and mutagenic in mammalian assays in vitro and in vivo

Compounds used to produce cloned animals are genotoxic and mutagenic in mammalian assays in vitro and in vivo

The compounds 6-dimethylaminopurine and cycloheximide promote the successful production of cloned mammals and have been used in the development of embryos produced by somatic cell nuclear transfer. This study investigated the effects of 6-dimethylaminopurine and cycloheximide in vitro, using the thi...

Full description

Bibliographic Details
Main Authors:	R.J. Oliveira, M.S. Mantovani, A.F. da Silva, J.R. Pesarini, M.O. Mauro, L.R. Ribeiro
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica 2014-04-01
Series:	Brazilian Journal of Medical and Biological Research
Subjects:	Somatic cell nuclear transfer 6-Dimethylaminopurine Cycloheximide Genotoxic Mutagenic
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000400287&lng=en&tlng=en

Similar Items

Studies of genotoxicity and mutagenicity of nitroimidazoles: demystifying this critical relationship with the nitro group
by: Núbia Boechat, et al.
Published: (2015-06-01)

Genotoxicity and mutagenicity assessment of electronic cigarette liquids
by: Hajed M. Al-Otaibi, et al.
Published: (2024-07-01)

In Vitro Mutagenic and Genotoxic Assessment of Anatoxin-a Alone and in Combination with Cylindrospermopsin
by: Cristina Plata-Calzado, et al.
Published: (2023-07-01)

MicotoXilico: An Interactive Database to Predict Mutagenicity, Genotoxicity, and Carcinogenicity of Mycotoxins
by: Josefa Tolosa, et al.
Published: (2023-05-01)

Augmented cytotoxic, mutagenic and genotoxic response triggered by carvedilol and celecoxib combinations
by: Ali Attiq, et al.
Published: (2018-06-01)

Evaluation of the genotoxicity and mutagenicity of Ca3SiO5-based cement
by: Gisele Alborghetti NAI, et al.

In Vitro Mutagenic and Genotoxic Assessment of a Mixture of the Cyanotoxins Microcystin-LR and Cylindrospermopsin
by: Leticia Díez-Quijada, et al.
Published: (2019-06-01)

Evidence for safety of the dietary ingredient agmatine sulfate as assessed by mutagenicity and genotoxicity studies
by: Varda H. Gilad, et al.
Published: (2024-12-01)

Investigation of genotoxicity, mutagenicity, and cytotoxicity in erythrocytes of Nile tilapia (Oreochromis niloticus) after fluoxetine exposure
by: Pachara Vijitkul, et al.
Published: (2022-01-01)

Evaluation of Mutagenicity and Anti-Mutagenicity of Various Bean Milks Using <i>Drosophila</i> with High Bioactivation
by: Woorawee Inthachat, et al.
Published: (2022-10-01)

Assessment of genotoxic and mutagenic effects of food products by bioassay methods
by: M. V. Zaytseva
Published: (2021-07-01)

A Nonclinical Safety Evaluation of Cold Atmospheric Plasma for Medical Applications: The Role of Genotoxicity and Mutagenicity Studies
by: Piimwara Yarangsee, et al.
Published: (2024-06-01)

Genotoxicity of Graphene-Based Materials
by: Josefa Domenech, et al.
Published: (2022-05-01)

In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents
by: Ana Claudia Manoel Von Trompowsky, et al.

Phytochemical properties and in-vitro cytotoxicity, genotoxicity and mutagenicity assessment of ethanolic and aqueous extracts of Argyrolobium roseum (Camb.)
by: Naeem Rasool, et al.
Published: (2023-09-01)

In vitro cytotoxicity and genotoxicity assessment of methanolic extracts of vanillas from Brazilian biodiversity with commercial potential
by: Natália Gonçalves Ribeiro Araujo, et al.
Published: (2024-12-01)

Differential genotoxicity of diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2
by: Daiane Francine Meinerz, et al.
Published: (2014-03-01)

Common Considerations for Genotoxicity Assessment of Nanomaterials
by: Rosalie K. Elespuru, et al.
Published: (2022-05-01)

Challenges of young scientists at the cutting-edge of genotoxicity research: the open symposium of the Japanese Environmental Mutagen Society (JEMS), 2018
by: Manabu Yasui, et al.
Published: (2018-11-01)

Physicochemical characterization and oxidative potential of size fractionated Particulate Matter: Uptake, genotoxicity and mutagenicity in V-79 cells
by: Kavita Dubey, et al.
Published: (2022-12-01)

Effects of Phenols from Olive Vegetation Water on Mutagenicity and Genotoxicity of Stored-Cooked Beef Patties
by: Dario Mercatante, et al.
Published: (2024-06-01)

Mutagenic, Genotoxic and Immunomodulatory effects of Hydroxychloroquine and Chloroquine: a review to evaluate its potential to use as a prophylactic drug against COVID-19
by: Allan Giri, et al.
Published: (2020-09-01)

The Potential for Genotoxicity, Mutagenicity and Endocrine Disruption in Triclosan and Triclocarban Assessed through a Combination of In Vitro Methods
by: Jan Chrz, et al.
Published: (2023-12-01)

A systematic quality evaluation and review of nanomaterial genotoxicity studies: a regulatory perspective
by: Kirsi K. Siivola, et al.
Published: (2022-09-01)

Genotoxic and Mutagenic Effects of the <i>Alternaria</i> Mycotoxin Alternariol in Combination with the Process Contaminant Acrylamide
by: Francesco Crudo, et al.
Published: (2023-11-01)

Study of Genotoxic Properties of Thiosonide
by: A. Yu. Sаvchenko, et al.
Published: (2021-07-01)

Assessment of the Cytotoxicity, Mutagenicity, and Genotoxicity of Two Traditional Chinese Herbs: <i>Aristolochia baetica</i> and <i>Magnolia officinalis</i>
by: Mélanie Poivre, et al.
Published: (2023-01-01)

Modulation of the mutagenic effect of benzo[a]pyrene and bleomycin by isoflavone extracts in a rat hepatoma cell line<br> Modulação do efeito mutagênico do benzo[a]pireno e bleomicina por extratos de isoflavonas em células de hepatoma de roedor
by: Mário Sérgio Mantovani, et al.
Published: (2012-06-01)

Carbon nanotubes: an insight into the mechanisms of their potential genotoxicity
by: Damien van Berlo, et al.
Published: (2012-11-01)

In Vitro Genotoxicity Assessment of Functional Ingredients: Betaine, Choline, and Taurine
by: Julen Sanz-Serrano, et al.
Published: (2021-02-01)

Mutagenicity of Ochratoxin A and Its Hydroquinone Metabolite in the SupF Gene of the Mutation Reporter Plasmid Ps189
by: Richard A. Manderville, et al.
Published: (2012-04-01)

Assessment of the Mutagenicity of Propolis Compounds from the Brazilian Cerrado Biome in Somatic Cells of Drosophila melanogaster
by: Fábio Henrique Fernandes, et al.
Published: (2019-10-01)

Ability of Allium cepa L. root tips and Tradescantia pallida var. purpurea in N-nitrosodiethylamine genotoxicity and mutagenicity evaluation
by: Claudia R. de Rainho, et al.
Published: (2010-12-01)

Mutagenicity potential (affect) of new atraumatic restorative treatment (ART) material incorporated with Azadirachta indica (Neem) against Salmonella typhimurium
by: P. Divya Kumari, et al.
Published: (2019-01-01)

Basic mutagenicity tests : UKEMS recommended procedures : UKEMS sub-committee on guidelines for mutagenicity testing : report, part 1 revised /
by: Kirkland, David J., et al.
Published: (2005)

Cytostatic Effects of Avocado Oil Using Single-cell Gel Electrophoresis (Comet Assay)
by: Subasini Uthirapathy
Published: (2023-01-01)

Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans
by: Edilson N Kaneshima, et al.
Published: (2005-05-01)

Dye detoxification by Lentinula edodes INCQS 40220
by: Ludmila R. Bergsten-Torralba, et al.
Published: (2016-02-01)

Dye detoxification by Lentinula edodes INCQS 40220
by: Ludmila R. Bergsten-Torralba, et al.
Published: (2016-02-01)

Mutagenicity of plant flavonols in the Salmonella/mammalian microsome test: activation of flavonol glycosides by mixed glycosidases from rat cecal bacteria and other sources /
by: 453871 Brown, Joseph P., et al.