Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes

Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes

Several pathways and/or genes have been shown to be dysregulated in obesity-induced insulin resistance (IR) and type 2 diabetes (T2D). We previously showed, for the first time, impaired expression of DNAJB3 mRNA and protein in subjects with obesity, which was concomitant with increased metabolic str...

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Bibliographic Details
Main Authors: Shadi Nejat, Kalhara R. Menikdiwela, Aliyah Efotte, Shane Scoggin, Bolormaa Vandanmagsar, Paul J. Thornalley, Mohammed Dehbi, Naima Moustaid-Moussa
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Genes
Subjects:
obesity
type 2 diabetes
heat shock proteins
DNAJB3
adipose tissue
CRISPR-Cas9
Online Access:https://www.mdpi.com/2073-4425/14/10/1857

Internet

https://www.mdpi.com/2073-4425/14/10/1857

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