The hope and hype of ellagic acid and urolithins as ligands of SARS-CoV-2 Nsp5 and inhibitors of viral replication

The hope and hype of ellagic acid and urolithins as ligands of SARS-CoV-2 Nsp5 and inhibitors of viral replication

Non-structural protein 5 (Nsp5) is a cysteine protease that plays a key role in SARS-CoV-2 replication, suppressing host protein synthesis and promoting immune evasion. The investigation of natural products as a potential strategy for Nsp5 inhibition is gaining attention as a means of developing ant...

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Bibliographic Details
Main Authors: Elisa Bianconi, Anna Gidari, Maria Souma, Samuele Sabbatini, Deborah Grifagni, Carlo Bigiotti, Elisabetta Schiaroli, Lucia Comez, Alessandro Paciaroni, Francesca Cantini, Daniela Francisci, Antonio Macchiarulo
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Antiviral
urolithins
microscale thermophoresis
polyphenols
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2023.2251721

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2023.2251721

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