Synthetic design of farnesyl-electrostatic peptides for development of a protein kinase A membrane translocation switch

Abstract Molecular switches that respond to a biochemical stimulus in cells have proven utility as a foundation for developing molecular sensors and actuators that could be used to address important biological questions. Developing a molecular switch unfortunately remains difficult as it requires el...

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Bibliographic Details
Main Authors: Allen K. Kim, Helen D. Wu, Takanari Inoue
Format: Article
Language:English
Published: Nature Portfolio 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-95840-8