Aberrant expression of GTPase-activating protein ARAP1 triggers circular dorsal ruffles associated with malignancy in hepatocellular carcinoma Hep3B cells

Aberrant expression of GTPase-activating protein ARAP1 triggers circular dorsal ruffles associated with malignancy in hepatocellular carcinoma Hep3B cells

Abstract Background Circular dorsal ruffles (CDRs) are large and rounded membrane ruffles that function as precursors of macropinocytosis. We recently reported that CDRs form in Hep3B hepatocellular carcinoma (HCC) cells, but not in Huh7 and HepG2 HCC cells or LO2 cells, suggesting that an unknown m...

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Bibliographic Details
Main Authors: Xiaowei Sun, Yanan Li, Yuxin He, Longjiao Cheng, Li Wang, Jinzi Wei, Jianan Chen, Linxuan Du, Zhongyang Shen, Yan Xie, Adam C. Midgley, Wentao Jiang, Sei Yoshida
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cell Communication and Signaling
Subjects:
Circular dorsal ruffles
Macropinocytosis
ARAP1
Hepatocellular carcinoma
Online Access:https://doi.org/10.1186/s12964-025-02084-4

Internet

https://doi.org/10.1186/s12964-025-02084-4

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