Aberrant expression of GTPase-activating protein ARAP1 triggers circular dorsal ruffles associated with malignancy in hepatocellular carcinoma Hep3B cells

Aberrant expression of GTPase-activating protein ARAP1 triggers circular dorsal ruffles associated with malignancy in hepatocellular carcinoma Hep3B cells

Abstract Background Circular dorsal ruffles (CDRs) are large and rounded membrane ruffles that function as precursors of macropinocytosis. We recently reported that CDRs form in Hep3B hepatocellular carcinoma (HCC) cells, but not in Huh7 and HepG2 HCC cells or LO2 cells, suggesting that an unknown m...

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Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Xiaowei Sun, Yanan Li, Yuxin He, Longjiao Cheng, Li Wang, Jinzi Wei, Jianan Chen, Linxuan Du, Zhongyang Shen, Yan Xie, Adam C. Midgley, Wentao Jiang, Sei Yoshida
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: BMC 2025-02-01
Sraith:Cell Communication and Signaling
Ábhair:
Circular dorsal ruffles
Macropinocytosis
ARAP1
Hepatocellular carcinoma
Rochtain ar líne:https://doi.org/10.1186/s12964-025-02084-4

Ar líne

https://doi.org/10.1186/s12964-025-02084-4

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