AMPK protects endothelial cells against HSV-1 replication via inhibition of mTORC1 and ACC1

AMPK protects endothelial cells against HSV-1 replication via inhibition of mTORC1 and ACC1

ABSTRACT Herpes simplex virus type 1 (HSV-1) is a widespread contagious pathogen, mostly causing mild symptoms on the mucosal entry side. However, systemic distribution, in particular upon reactivation of the virus in immunocompromised patients, may trigger an innate immune response and induce damag...

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Bibliographic Details
Main Authors: Heena Doshi, Katrin Spengler, Amod Godbole, Yi Sing Gee, Jonathan Baell, Jonathan S. Oakhill, Andreas Henke, Regine Heller
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:Microbiology Spectrum
Subjects:
HSV-1
AMPK
MK-8722
ACC
mTORC
endothelial cells
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00417-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.00417-23

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