Propagation of Fibrillar Structural Forms in Proteins Stopped by Naturally Occurring Short Polypeptide Chain Fragments

Propagation of Fibrillar Structural Forms in Proteins Stopped by Naturally Occurring Short Polypeptide Chain Fragments

Amyloids characterized by unbounded growth of fibrillar structures cause many pathological processes. Such unbounded propagation is due to the presence of a propagating hydrophobicity field around the fibril’s main axis, preventing its closure (unlike in globular proteins). Interestingly, similar fr...

Full description

Bibliographic Details
Main Authors: Irena Roterman, Mateusz Banach, Leszek Konieczny
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Pharmaceuticals
Subjects:
amyloid
hydrophobicity
fibrillation
solenoid
Online Access:https://www.mdpi.com/1424-8247/10/4/89

Internet

https://www.mdpi.com/1424-8247/10/4/89

Similar Items